The Competence Center InterSurf comprises our activities concerning the interaction at, in, and on Surfaces and Interfaces. The aim is to understand and design "active" interfaces and structures, which respond in a desired way to triggers from the local environment, such as forces, electronic potentials, and light, with respect to tasks in medicine and energy supply. The application background comprises electrically active implant surfaces, initiation and control of cellular programs, and materials and structures for energy transport. Nanostructuration- and nanomanipulation protocols for interfaces are developed, in order to arrange for dedicated structures, the function of them can be locally initiated, measured and comprehended. In an number of pilot studies and projects we aim to identify the most promising questions and approaches in order to implement those as interdisciplinary collaborative projects.